Transforming Growth Factor-β-stimulated Endocardial Cell Transformation Is Dependent on Par6c Regulation of RhoA

Valvular heart disease due to congenital abnormalities or pathology is a major cause of mortality and morbidity. Understanding the cellular processes and molecules that regulate valve formation and remodeling is required to develop effective therapies. In the developing heart, epithelial-mesenchymal...

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Главные авторы: Townsend, Todd A., Wrana, Jeffrey L., Davis, George E., Barnett, Joey V.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2008
Предметы:
Molecular Basis of Cell and Developmental Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376225/
https://ncbi.nlm.nih.gov/pubmed/18343818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710607200
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