Requirement of Inositol 1,4,5-Trisphosphate Receptors for Tumor-mediated Lymphocyte Apoptosis

Tumor cells strategically down-regulate Fas receptor expression to evade immune attack and up-regulate expression of Fas ligand to promote apoptosis of infiltrating T lymphocytes. Many pathways leading to apoptotic cell death require calcium release from inositol 1,4,5-trisphosphate receptors (IP(3)...

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Bibliographic Details
Main Authors: Steinmann, Camia, Landsverk, Megan L., Barral, José M., Boehning, Darren
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376216/
https://ncbi.nlm.nih.gov/pubmed/18364356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C800029200
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