Apoptotic mechanisms in T47D and MCF-7 human breast cancer cells

To investigate the mechanisms underlying apoptosis in breast cancer cells, staurosporine was used as an apoptotic stimulus in the human breast cancer cell lines MCF-7 and T47D. Staurosporine induced dose and time dependent increases in DNA fragmentation which was abrogated by z-VAD-fmk. MCF-7 cells...

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Hlavní autoři: Mooney, L M, Al-Sakkaf, K A, Brown, B L, Dobson, P R M
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2002
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376174/
https://ncbi.nlm.nih.gov/pubmed/12373608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600541
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