The antitumour activity of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF receptor-1 knockout mice

5,6-dimethylxanthenone-4-acetic acid, a novel antivascular anticancer drug, has completed Phase I clinical trial. Its actions in mice include tumour necrosis factor induction, serotonin release, tumour blood flow inhibition, and the induction of tumour haemorrhagic necrosis and regression. We have u...

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Bibliografiske detaljer
Main Authors: Zhao, L, Ching, L-M, Kestell, P, Baguley, B C
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2002
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376130/
https://ncbi.nlm.nih.gov/pubmed/12177785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600479
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