Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas

Germline mutations in the fumarate hydratase gene at 1q43 predispose to dominantly inherited skin and uterine leiomyomata and leiomyosarcomas. The enzyme, which is a component of the tricarboxylic acid cycle, acts as a tumour suppressor. To evaluate fumarate hydratase in respective sporadic tumours,...

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Detalhes bibliográficos
Main Authors: Barker, K T, Bevan, S, Wang, R, Lu, Y-J, Flanagan, A M, Bridge, J A, Fisher, C, Finlayson, C J, Shipley, J, Houlston, R S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2002
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376129/
https://ncbi.nlm.nih.gov/pubmed/12177782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600502
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