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Spike Ca(2+) influx upmodulates the spike afterdepolarization and bursting via intracellular inhibition of K(V)7/M channels
In principal brain neurons, activation of Ca(2+) channels during an action potential, or spike, causes Ca(2+) entry into the cytosol within a millisecond. This in turn causes rapid activation of large conductance Ca(2+)-gated channels, which enhances repolarization and abbreviates the spike. Here we...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Blackwell Science Inc
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2375679/ https://ncbi.nlm.nih.gov/pubmed/18187471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.148171 |
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