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Proximal Persistent Na(+) Channels Drive Spike Afterdepolarizations and Associated Bursting in Adult CA1 Pyramidal Cells

In many principal brain neurons, the fast, all-or-none Na(+) spike initiated at the proximal axon is followed by a slow, graded afterdepolarization (ADP). The spike ADP is critically important in determining the firing mode of many neurons; large ADPs cause neurons to fire bursts of spikes rather th...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Yue, Cuiyong, Remy, Stefan, Su, Hailing, Beck, Heinz, Yaari, Yoel
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725731/
https://ncbi.nlm.nih.gov/pubmed/16237175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1621-05.2005
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