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The tumour-suppressor p53 is not required for pancreatic β cell death during diabetes and upon irradiation

Immune-independent diabetes often occurs via pancreatic β cell dysfunction. However, the role of the tumour suppressor p53 that regulates cellular life and death in multiple tissues, in pancreatic cell death and diabetes has not been clarified. We have therefore utilized an established mouse model f...

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Hlavní autoři: Nam, Shin Yuen, Lee, Ming Kei, Sabapathy, Kanaga
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375583/
https://ncbi.nlm.nih.gov/pubmed/18006584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.142612
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