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Inhibition of the alpha-ν integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo

Anti-angiogenetic cancer therapy is a potential new form for treatment of solid tumours. The α(v)-integrins (α(v)β(3), α(v)β(5)) mediate the contact of activated endothelial cells to proteins of the extracellular matrix during tumour angiogenesis as a prerequisite for survival of endothelial cells....

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Detalhes bibliográficos
Main Authors: Buerkle, M A, Pahernik, S A, Sutter, A, Jonczyk, A, Messmer, K, Dellian, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375318/
https://ncbi.nlm.nih.gov/pubmed/11875744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600141
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