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Phase I study of the combination of losoxantrone and cyclophosphamide in patients with refractory solid tumours

Losoxantrone is a DNA intercalator that was developed with the potential to replace anthracyclines. The recommended single agent dose of losoxantrone is 50 mg m(−2) every 3 weeks. We conducted a phase I study of losoxantrone and a fixed dose of cyclophosphamide on a q3 weekly schedule. Forty-nine pa...

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Autores principales: Goh, B C, Vokes, E E, Joshi, A, Ratain, M J
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2002
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375276/
https://ncbi.nlm.nih.gov/pubmed/11870533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600123
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