Antagomir-17-5p Abolishes the Growth of Therapy-Resistant Neuroblastoma through p21 and BIM

We identified a key oncogenic pathway underlying neuroblastoma progression: specifically, MYCN, expressed at elevated level, transactivates the miRNA 17-5p-92 cluster, which inhibits p21 and BIM translation by interaction with their mRNA 3′ UTRs. Overexpression of miRNA 17-5p-92 cluster in MYCN-not-...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Fontana, Laura, Fiori, Micol E., Albini, Sonia, Cifaldi, Loredana, Giovinazzi, Serena, Forloni, Matteo, Boldrini, Renata, Donfrancesco, Alberto, Federici, Valentina, Giacomini, Patrizio, Peschle, Cesare, Fruci, Doriana
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2008
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375057/
https://ncbi.nlm.nih.gov/pubmed/18493594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002236
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg