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TAR RNA binding properties and relative transactivation activities of human immunodeficiency virus type 1 and 2 Tat proteins.

Using gel shift assays, we found that the human immunodeficiency virus type 1 (HIV-1) Tat protein (Tat-1) bound both HIV-1 and HIV-2 TAR RNAs with similar high affinities. In contrast, the HIV-2 Tat protein (Tat-2) bound only TAR-2 RNA with high affinity. We conclude that the weak in vivo activity o...

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Gardado en:
Publicado en:J Virol
Principais autores: Rhim, H, Rice, A P
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 1993
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237470/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8419640/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.2.1110-1121.1993
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