Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis

INTRODUCTION: High mobility group box chromosomal protein 1 (HMGB1) is a nuclear protein that acts as a pro-inflammatory mediator following extracellular release. The protein is aberrantly expressed extracellularly in the settings of clinical and experimental synovitis. Therapy based on HMGB1 antago...

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Main Authors: Östberg, Therese, Wähämaa, Heidi, Palmblad, Karin, Ito, Norimasa, Stridh, Pernilla, Shoshan, Maria, Lotze, Michael T, Harris, Helena Erlandsson, Andersson, Ulf
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374449/
https://ncbi.nlm.nih.gov/pubmed/18179697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2347
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