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Preclinical evaluation of the cardiac toxicity of HMR-1826, a novel prodrug of doxorubicin
Cardiotoxicity represents the major side-effect limiting the clinical use of anthracyclines, especially doxorubicin, in cancer chemotherapy. The use of non-toxic prodrugs, or of liposome-encapsulated drugs, allows a better targeting of the tumours and may, therefore, improve the tolerance to the tre...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2374342/ https://ncbi.nlm.nih.gov/pubmed/10487608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690646 |
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