Structural basis for chloramphenicol tolerance in Streptomyces venezuelae by chloramphenicol phosphotransferase activity

Streptomyces venezuelae synthesizes chloramphenicol (Cm), an inhibitor of ribosomal peptidyl transferase activity, thereby inhibiting bacterial growth. The producer escapes autoinhibition by its own secondary metabolite through phosphorylation of Cm by chloramphenicol phosphotransferase (CPT). In ad...

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Bibliografiska uppgifter
Huvudupphovsman: Izard, Tina
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2001
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374082/
https://ncbi.nlm.nih.gov/pubmed/11468347
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