Structural basis for the substrate recognition of aminoglycoside 7′′-phosphotransferase-Ia from Streptomyces hygroscopicus

Hygromycin B (HygB) is one of the aminoglycoside antibiotics, and it is widely used as a reagent in molecular-biology experiments. Two kinases are known to inactivate HygB through phosphorylation: aminoglycoside 7′′-phosphotransferase-Ia [APH(7′′)-Ia] from Streptomyces hygroscopicus and aminoglycosi...

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Publicat a:Acta Crystallogr F Struct Biol Commun
Autors principals: Takenoya, Mihoko, Shimamura, Tatsuro, Yamanaka, Ryuji, Adachi, Yuya, Ito, Shinsaku, Sasaki, Yasuyuki, Nakamura, Akira, Yajima, Shunsuke
Format: Artigo
Idioma:Inglês
Publicat: International Union of Crystallography 2019
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718145/
https://ncbi.nlm.nih.gov/pubmed/31475927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X19011105
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