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The N-terminal portion of mature aldehyde dehydrogenase affects protein folding and assembly

Human liver cytosolic (ALDH1) and mitochondrial (ALDH2) aldehyde dehydrogenases are both encoded in the nucleus and synthesized in the cytosol. ALDH1 must fold in the cytosol, but ALDH2 is first synthesized as a precursor and must remain unfolded during import into mitochondria. The two mature forms...

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Bibliografske podrobnosti
Main Authors: Zhou, Jianzhong, Weiner, Henry
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2001
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374079/
https://ncbi.nlm.nih.gov/pubmed/11468345
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