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Proton transfer dynamics of GART: The pH-dependent catalytic mechanism examined by electrostatic calculations
The enzyme glycinamide ribonucleotide transformylase (GART) catalyzes the transfer of a formyl group from formyl tetrahydrofolate (fTHF) to glycinamide ribonucleotide (GAR), a process that is pH-dependent with pK(a) of ∼8. Experimental studies of pH-rate profiles of wild-type and site-directed mutan...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2001
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2374072/ https://ncbi.nlm.nih.gov/pubmed/11604543 |
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