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Efficacious Recombinant Influenza Vaccines Produced by High Yield Bacterial Expression: A Solution to Global Pandemic and Seasonal Needs

It is known that physical linkage of TLR ligands and vaccine antigens significantly enhances the immunopotency of the linked antigens. We have used this approach to generate novel influenza vaccines that fuse the globular head domain of the protective hemagglutinin (HA) antigen with the potent TLR5...

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Autores principales: Song, Langzhou, Nakaar, Valerian, Kavita, Uma, Price, Albert, Huleatt, Jim, Tang, Jie, Jacobs, Andrea, Liu, Ge, Huang, Yan, Desai, Priyanka, Maksymiuk, Gail, Takahashi, Virginia, Umlauf, Scott, Reiserova, Lucia, Bell, Rodney, Li, Hong, Zhang, Yi, McDonald, William F., Powell, T. J., Tussey, Lynda
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373928/
https://ncbi.nlm.nih.gov/pubmed/18493310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002257
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