Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis

Bone sialoprotein (BSP) and osteopontin (OPN) are both highly expressed in bone, but their functional specificities are unknown. OPN knockout ((−/−)) mice do not lose bone in a model of hindlimb disuse (tail suspension), showing the importance of OPN in bone remodeling. We report that BSP(−/−) mice...

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Autors principals: Malaval, Luc, Wade-Guéye, Ndéyé Marième, Boudiffa, Maya, Fei, Jia, Zirngibl, Ralph, Chen, Frieda, Laroche, Norbert, Roux, Jean-Paul, Burt-Pichat, Brigitte, Duboeuf, François, Boivin, Georges, Jurdic, Pierre, Lafage-Proust, Marie-Hélène, Amédée, Joëlle, Vico, Laurence, Rossant, Janet, Aubin, Jane E.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2008
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373846/
https://ncbi.nlm.nih.gov/pubmed/18458111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071294
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