Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma

We conducted a Phase I clinical trial investigating the biologic activity of vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage colony-stimulating factor in patients with metastatic melanoma. Immunization sites were intensely infiltrated with T l...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Soiffer, Robert, Lynch, Thomas, Mihm, Martin, Jung, Ken, Rhuda, Catherine, Schmollinger, Jan C., Hodi, F. Stephen, Liebster, Laura, Lam, Prudence, Mentzer, Steven, Singer, Samuel, Tanabe, Kenneth K., Cosimi, A. Benedict, Duda, Rosemary, Sober, Arthur, Bhan, Atul, Daley, John, Neuberg, Donna, Parry, Gordon, Rokovich, Joseph, Richards, Laurie, Drayer, Jan, Berns, Anton, Clift, Shirley, Cohen, Lawrence K., Mulligan, Richard C., Dranoff, Glenn
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23738/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9789055/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.22.13141
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