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Enzymatic activity of poliovirus RNA polymerases with mutations at the tyrosine residue of the conserved YGDD motif: isolation and characterization of polioviruses containing RNA polymerases with FGDD and MGDD sequences.

The poliovirus RNA-dependent RNA polymerase (3Dpol) shares a region of homology with all RNA polymerases, centered around the amino acid motif YGDD, which has been postulated to be involved in the catalytic activity of the enzyme. Using oligonucleotide site-directed mutagenesis, we substituted the t...

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Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Jablonski, S A, Morrow, C D
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 1993
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237373/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8380083/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.1.373-381.1993
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