A "string-of-beads" vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge.

We have previously demonstrated that induction of antiviral cytotoxic T lymphocytes (CTL), in the absence of antiviral antibodies, can confer protection against a lethal-dose virus challenge. Here we extend those findings as follows. First, three discrete viral CTL epitopes expressed from minigenes...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Whitton, J L, Sheng, N, Oldstone, M B, McKee, T A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237369/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7677954/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.1.348-352.1993
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