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Role of water in the catalytic cycle of E. coli dihydrofolate reductase
Dihydrofolate reductase (DHFR) catalyzes the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of 7,8-dihydrofolate (H(2)F) to 5,6,7,8-tetrahydrofolate (H(4)F). Because of the absence of any ionizable group in the vicinity of N5 of dihydrofolate it has been proposed that N5 cou...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2373639/ https://ncbi.nlm.nih.gov/pubmed/12021443 |
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