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Analysis of serine proteinase–inhibitor interaction by alanine shaving

We analyzed the energetic importance of residues surrounding the hot spot (the P(1) position) of bovine pancreatic trypsin inhibitor (BPTI) in interaction with two proteinases, trypsin and chymotrypsin, by a procedure called molecular shaving. One to eight residues of the structural epitope, compose...

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Autori principali: Buczek, Olga, Koscielska-Kasprzak, Katarzyna, Krowarsch, Daniel, Dadlez, Michał, Otlewski, Jacek
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373526/
https://ncbi.nlm.nih.gov/pubmed/11910024
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