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Low levels of asparagine deamidation can have a dramatic effect on aggregation of amyloidogenic peptides: Implications for the study of amyloid formation

The polypeptide hormone amylin forms amyloid deposits in Type 2 diabetes mellitus and a 10-residue fragment of amylin (amylin(20–29)) is commonly used as a model system to study this process. Studies of amylin(20–29) and several variant peptides revealed that low levels of deamidation can have a sig...

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Autores principales: Nilsson, Melanie R., Driscoll, Miles, Raleigh, Daniel P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2002
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373442/
https://ncbi.nlm.nih.gov/pubmed/11790844
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