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Rapid structural fluctuations of the free HIV protease flaps in solution: Relationship to crystal structures and comparison with predictions of dynamics calculations

Crystal structures have shown that the HIV-1 protease flaps, domains that control access to the active site, are closed when the active site is occupied by a ligand. Although flap structures ranging from closed to semi-open are observed in the free protease, crystal structures reveal that even the s...

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Main Authors: Freedberg, Darón I., Ishima, Rieko, Jacob, Jaison, Wang, Yun-Xing, Kustanovich, Irina, Louis, John M., Torchia, Dennis A.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2002
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373438/
https://ncbi.nlm.nih.gov/pubmed/11790832
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