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Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13
Wnt target gene transcription is mediated by nuclear translocation of stabilized β-catenin, which binds to TCF and recruits Pygopus, a cofactor with an unknown mechanism of action. The mediator complex is essential for the transcription of RNA polymerase II-dependent genes; it associates with an acc...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2373359/ https://ncbi.nlm.nih.gov/pubmed/18451032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709749105 |
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