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Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13

Wnt target gene transcription is mediated by nuclear translocation of stabilized β-catenin, which binds to TCF and recruits Pygopus, a cofactor with an unknown mechanism of action. The mediator complex is essential for the transcription of RNA polymerase II-dependent genes; it associates with an acc...

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Bibliografiske detaljer
Main Authors: Carrera, Inés, Janody, Florence, Leeds, Nina, Duveau, Fabien, Treisman, Jessica E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373359/
https://ncbi.nlm.nih.gov/pubmed/18451032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709749105
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