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Structural and mechanistic insight into the basis of mucopolysaccharidosis IIIB
Mucopolysaccharidosis III (MPS III) has four forms (A–D) that result from buildup of an improperly degraded glycosaminoglycan in lysosomes. MPS IIIB is attributable to the decreased activity of a lysosomal α-N-acetylglucosaminidase (NAGLU). Here, we describe the structure, catalytic mechanism, and i...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2373330/ https://ncbi.nlm.nih.gov/pubmed/18443291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711491105 |
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