Substitutions in the capsids of poliovirus mutants selected in human neuroblastoma cells confer on the Mahoney type 1 strain a phenotype neurovirulent in mice.

Poliovirus (PV) type 1 mutants selected in human neuroblastoma cells persistently infected (PVpi) with the wild-type Mahoney strain exhibited a mouse-neurovirulent phenotype. Four of the five substitutions present in the capsid proteins of a PVpi were demonstrated to extend the host range of the Mah...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Couderc, T, Guédo, N, Calvez, V, Pelletier, I, Hogle, J, Colbère-Garapin, F, Blondel, B
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 1994
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237308/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7966631/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.12.8386-8391.1994
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