Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics.

The hepatitis C virus H strain (HCV-H) polyprotein is cleaved to produce at least 10 distinct products, in the order of NH2-C-E1-E2-p7-NS2-NS3-NS4A-NS4B-NS5A-NS5B -COOH. An HCV-encoded serine proteinase activity in NS3 is required for cleavage at four sites in the nonstructural region (3/4A, 4A/4B,...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Lin, C, Prágai, B M, Grakoui, A, Xu, J, Rice, C M
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1994
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237280/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7966606/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.12.8147-8157.1994
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