Selectable retrovirus vectors encoding Friend virus gp55 or erythropoietin induce polycythemia with different phenotypic expression and disease progression.

The Friend spleen focus-forming virus induces a massive expansion of erythroid progenitor cells resulting in polycythemia and splenomegaly. The pathogenic agent is the membrane glycoprotein gp55, encoded by the env gene. Recent evidence indicates that gp55 binds to and activates the erythropoietin (...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Ahlers, N, Hunt, N, Just, U, Laker, C, Ostertag, W, Nowock, J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237163/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7933106/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.11.7235-7243.1994
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