Host range and cell cycle activation properties of polyomavirus large T-antigen mutants defective in pRB binding.

We have examined the growth properties of polyomavirus large T-antigen mutants that are unable to bind pRB, the product of the retinoblastoma tumor suppressor gene. These mutants grow poorly on primary mouse cells yet grow well on NIH 3T3 and other established mouse cell lines. Preinfection of prima...

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Publié dans:	J Virol
Auteurs principaux:	Freund, R, Bauer, P H, Crissman, H A, Bradbury, E M, Benjamin, T L
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1994
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237162/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7933105/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.11.7227-7234.1994
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