Host range and cell cycle activation properties of polyomavirus large T-antigen mutants defective in pRB binding.

We have examined the growth properties of polyomavirus large T-antigen mutants that are unable to bind pRB, the product of the retinoblastoma tumor suppressor gene. These mutants grow poorly on primary mouse cells yet grow well on NIH 3T3 and other established mouse cell lines. Preinfection of prima...

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Bibliographic Details
Published in:J Virol
Main Authors: Freund, R, Bauer, P H, Crissman, H A, Bradbury, E M, Benjamin, T L
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1994
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237162/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7933105/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.11.7227-7234.1994
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