Tyrosine kinase activity may be necessary but is not sufficient for c-erbB1-mediated tissue-specific tumorigenicity.

Expression of mutant avian c-erbB1 genes results in tissue-specific transformation in chickens. Site-directed mutagenesis was used to generate kinase-defective mutants of several tissue-specific v-erbB transforming mutants by replacement of the ATP-binding lysine residue in the kinase domain with an...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Connolly, D C, Toutenhoofd, S L, Maihle, N J
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237108/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7916062/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.10.6804-6810.1994
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