Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins.

The proteolytic cleavages at the NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B junctions of hepatitis C virus (HCV) polyprotein are effected by the virus-encoded serine protease contained within NS3. Using transient expression in HeLa cells of cDNA fragments that code for regions of the HCV polyprot...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Failla, C, Tomei, L, De Francesco, R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236880/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8189513/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.6.3753-3760.1994
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