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Mutagenic study of codons 74 and 215 of the human immunodeficiency virus type 1 reverse transcriptase, which are significant in nucleoside analog resistance.

Mutation in the human immunodeficiency virus type 1 reverse transcriptase (RT) at codon 215 has been shown to play a significant role in resistance to zidovudine (AZT). Substitution of threonine with tyrosine or phenylalanine alone confers decreased susceptibility to the inhibitor. In this study we...

詳細記述

保存先:
書誌詳細
出版年:J Virol
主要な著者: Lacey, S F, Larder, B A
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 1994
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236837/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7512165/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.5.3421-3424.1994
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