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Mutagenic study of codons 74 and 215 of the human immunodeficiency virus type 1 reverse transcriptase, which are significant in nucleoside analog resistance.

Mutation in the human immunodeficiency virus type 1 reverse transcriptase (RT) at codon 215 has been shown to play a significant role in resistance to zidovudine (AZT). Substitution of threonine with tyrosine or phenylalanine alone confers decreased susceptibility to the inhibitor. In this study we...

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Библиографические подробности
Главные авторы: Lacey, S F, Larder, B A
Формат: Artigo
Язык:Inglês
Опубликовано: 1994
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC236837/
https://ncbi.nlm.nih.gov/pubmed/7512165
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