Hydroxylation Increases the Neurotoxic Potential of BDE-47 to Affect Exocytosis and Calcium Homeostasis in PC12 Cells

BACKGROUND: Oxidative metabolism, resulting in the formation of hydroxylated polybrominated diphenyl ether (PBDE) metabolites, may enhance the neurotoxic potential of brominated flame retardants. OBJECTIVE: Our objective was to investigate the effects of a hydroxylated metabolite of 2,2′,4,4′-tetra-...

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Detalhes bibliográficos
Main Authors: Dingemans, Milou M.L., de Groot, Aart, van Kleef, Regina G.D.M., Bergman, Åke, van den Berg, Martin, Vijverberg, Henk P.M., Westerink, Remco H.S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Institute of Environmental Health Sciences 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367675/
https://ncbi.nlm.nih.gov/pubmed/18470311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.11059
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