Specific Lipids Supply Critical Negative Spontaneous Curvature—An Essential Component of Native Ca(2+)-Triggered Membrane Fusion

The Ca(2+)-triggered merger of two apposed membranes is the defining step of regulated exocytosis. CHOL is required at critical levels in secretory vesicle membranes to enable efficient, native membrane fusion: CHOL-sphingomyelin enriched microdomains organize the site and regulate fusion efficiency...

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Autori principali: Churchward, Matthew A., Rogasevskaia, Tatiana, Brandman, David M., Khosravani, Houman, Nava, Phillip, Atkinson, Jeffrey K., Coorssen, Jens R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2008
Soggetti:
Membranes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367177/
https://ncbi.nlm.nih.gov/pubmed/18227127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.123984
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