Distinct Unfolding and Refolding Pathways of Ribonuclease A Revealed by Heating and Cooling Temperature Jumps

Heating and cooling temperature jumps (T-jumps) were performed using a newly developed technique to trigger unfolding and refolding of wild-type ribonuclease A and a tryptophan-containing variant (Y115W). From the linear Arrhenius plots of the microscopic folding and unfolding rate constants, activa...

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Bibliographic Details
Main Authors: Torrent, Joan, Marchal, Stéphane, Ribó, Marc, Vilanova, Maria, Georges, Cédric, Dupont, Yves, Lange, Reinhard
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2008
Subjects:
Proteins
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367170/
https://ncbi.nlm.nih.gov/pubmed/18234832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.123893
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