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ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity
Human fibroblasts, capable of expressing a kinase-dead form of ATR (ATRkd), can be sensitized to the cytotoxic effects of methyl methanesulfonate (MMS) by the PARP inhibitor 4-amino-1,8-naphthalimide (4-AN). The combination of MMS + 4-AN results in accumulation of cells in S-phase of the cell cycle...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2367098/ https://ncbi.nlm.nih.gov/pubmed/17292679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2006.12.015 |
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