α-Lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human α-lactalbumin made lethal to tumor cells)

HAMLET (human α-lactalbumin made lethal to tumor cells) is a complex of human α-lactalbumin and oleic acid (C18:1:9 cis) that kills tumor cells by an apoptosis-like mechanism. Previous studies have shown that a conformational change is required to form HAMLET from α-lactalbumin, and that a partially...

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Main Authors: Svensson, Malin, Fast, Jonas, Mossberg, Ann-Kristin, Düringer, Caroline, Gustafsson, Lotta, Hallgren, Oskar, Brooks, Charles L., Berliner, Lawrence, Linse, Sara, Svanborg, Catharina
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2366987/
https://ncbi.nlm.nih.gov/pubmed/14627739
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