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Stabilization of a metastable state of Torpedo californica acetylcholinesterase by chemical chaperones

Chemical modification of Torpedo californica acetylcholinesterase by the natural thiosulfinate allicin produces an inactive enzyme through reaction with the buried cysteine Cys 231. Optical spectroscopy shows that the modified enzyme is “native-like,” and inactivation can be reversed by exposure to...

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Main Authors: Millard, Charles B., Shnyrov, Valery L., Newstead, Simon, Shin, Irina, Roth, Esther, Silman, Israel, Weiner, Lev
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cold Spring Harbor Laboratory Press 2003
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2366936/
https://ncbi.nlm.nih.gov/pubmed/14500892
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