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Insulin-Like Growth Factor-Binding Protein-5 Inhibits Osteoblast Differentiation and Skeletal Growth by Blocking Insulin-Like Growth Factor Actions

Signaling through the IGF-I receptor by locally synthesized IGF-I or IGF-II is critical for normal skeletal development and for bone remodeling and repair throughout the lifespan. In most tissues, IGF actions are modulated by IGF-binding proteins (IGFBPs). IGFBP-5 is the most abundant IGFBP in bone,...

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Autores principales: Mukherjee, Aditi, Rotwein, Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: The Endocrine Society 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2366187/
https://ncbi.nlm.nih.gov/pubmed/18292241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0001
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