Antitumor Trans Platinum DNA Adducts: NMR and HPLC Study of the Interaction Between a trans-Pt Iminoether Complex and the Deoxy Decamer d(CCTCGCTCTC)·d(GAGAGCGAGG)

The single-stranded oligonucleotide 5′-d(CCTCGCTCTC) (I) was reacted with the antitumor trans platinum iminoderivative trans-[PtCl(2){E-HN = C(OMe)Me}(2)] (trans-EE) and subsequently annealed with its complementary strand 5′-d(GAGAGCGAGG) (II). The platinated duplex was characterized by 1D and 2D pr...

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Detalhes bibliográficos
Main Authors: Andersen, Bjørn, Margiotta, Nicola, Coluccia, Mauro, Natile, Giovanni, Sletten, Einar
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2000
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2365194/
https://ncbi.nlm.nih.gov/pubmed/18475920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/MBD.2000.23
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