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A specific orientation of RNA secondary structures is required for initiation of reverse transcription.

The 5' end of avian retrovirus RNA near the primer-binding site (PBS) forms two secondary structures, the U5-inverted repeat (U5-IR) and the U5-leader stems, and contains a 7-nucleotide sequence that anneals to the T psi C loop of the tRNA(Trp) primer. Mutations that disrupt any of these base pair i...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Aiyar, A, Ge, Z, Leis, J
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 1994
Soggetti:
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236493/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7507181/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.2.611-618.1994
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