A specific orientation of RNA secondary structures is required for initiation of reverse transcription.
The 5' end of avian retrovirus RNA near the primer-binding site (PBS) forms two secondary structures, the U5-inverted repeat (U5-IR) and the U5-leader stems, and contains a 7-nucleotide sequence that anneals to the T psi C loop of the tRNA(Trp) primer. Mutations that disrupt any of these base pair i...
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| Udgivet i: | J Virol |
|---|---|
| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
1994
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236493/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7507181/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.2.611-618.1994 |
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