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A specific orientation of RNA secondary structures is required for initiation of reverse transcription.

The 5' end of avian retrovirus RNA near the primer-binding site (PBS) forms two secondary structures, the U5-inverted repeat (U5-IR) and the U5-leader stems, and contains a 7-nucleotide sequence that anneals to the T psi C loop of the tRNA(Trp) primer. Mutations that disrupt any of these base p...

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Detalles Bibliográficos
Main Authors: Aiyar, A, Ge, Z, Leis, J
Formato: Artigo
Idioma:Inglês
Publicado: 1994
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC236493/
https://ncbi.nlm.nih.gov/pubmed/7507181
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