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Rho GDP Dissociation Inhibitor-Mediated Disruption of Rho GTPase Activity Impairs Lens Fiber Cell Migration, Elongation and Survival

To explore the role of the Rho GTPases in lens morphogenesis, we overexpressed bovine Rho GDP dissociation inhibitor (RhoGDIα), which serves as a negative regulator of Rho, Rac and Cdc42 GTPase activity, in a lens-specific manner in transgenic mice. This was achieved using a chimeric promoter of δ-c...

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Autors principals: Maddala, Rupalatha, Reneker, Lixing W., Pendurthi, Bhavana, Rao, Ponugoti V.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364637/
https://ncbi.nlm.nih.gov/pubmed/18234179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2007.12.039
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