Evidence that the herpes simplex virus type 1 uracil DNA glycosylase is required for efficient viral replication and latency in the murine nervous system.

Herpes simplex virus (HSV) encodes a uracil DNA glycosylase (UNG; UL2), which has been shown to be dispensable for normal replication of HSV-1 in cultured cells (J. Mullaney, H.W. Moss, and D.J. McGeoch, J. Gen. Virol. 70:449-454, 1989). In adult neurons, UNG activity is undetectable (F. Focher, P....

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Pyles, R B, Thompson, R L
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236437/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8035495/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.8.4963-4972.1994
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